PhD Scholarship CMCS/BDE/16

Call for Applications for PhD Scholarship at Hovione, Reference: CMCS/BDE/16

Call for Applications for a PhD Scholarship at Hovione (M/F)


Hovione FarmaCiencia SA (Hovione) is a Portuguese company specialized in Health sciences, dedicated to the research, development and production of Active Pharmaceutical Substances (APIs), and drug products for pulmonary inhalation and oral delivery. Hovione innovates and leads worldwide in the field of pharmaceutical chemistry, as demonstrated by about 400 worldwide patents. The products and procedures developed at Hovione meet the high standards of compliance established by the International Conference Harmonization (ICH), Food and Drug Administration (FDA) and Health Authorities of European countries and Japan.

As an integral part of Hovione's Innovation Strategy, the PhD program Development and validation of a Continuous manufacturability classification system was created and awarded a PhD in Business (BDE) scholarship.

Thus, under the terms of the ”Estatuto do Bolseiro de Investigação Ciêntifica”, approved by “Lei nº 40/2004” amended by “Decreto-Lei nº 202/2012”, of 27th August, and amended by “Decreto-Lei nº. 233/2012, of 29th October and by “lei nº12/2013, of 29th January and “Decreto-Lei nº. 89/2013”, of 9th July (Research Grants Regulation of the Foundation for Science and Technology (FCT)), now in force, a call for the selection of scholars and grant of an individual scholarship is open:


The present call is open to a PhD in Business (BDE) Scholarship under the conditions and characteristics set forth in Article 6 of the FCT Research Grant Regulation in force in 2021.

Pharmaceutical technology / Quality engineering

Masters in Chemical or Mechanical Engineering or Pharmaceutical Sciences with a minimum grade of 16 may apply for this call. Preference will be given to candidates with proven experience in areas related to the detailed work plan below and fluent in English. Personal characteristics: Enthusiasm, organization and objectivity; Analytical sense (attention to detail); Sense of responsibility and ethics; Ability to analyze and solve problems; Good interpersonal skills.

The activity of the scholar should focus on the following tasks:

  • Keep up-to-date with current scientific literature in the area of the study;
  • Risk assessment of continuous direct compression manufacturing process;
  • Design of a structured experimental design that will support definition of a Continuous Manufacturability Classification System (cMCS);
  • Performing tablet compression, powder flow and final product characterization tests as adequate;
  • Create innovative solutions in the area of formulation for continuous direct compression.

The aim of this work is to develop a Continuous Manufacturability Classification System (cMCS), that would allow for quick identification of the necessary formulation and process approaches leading towards successful continuous direct compression (CDC) implementation. Such system will allow for lean, material and cost saving approach to formulation for continuous tablet production line. In a further extent, it is expected that this work will enable exploring full benefit of CDC by adding capacity of processing complex formulations, lower or higher API load formulations, and most importantly, flag problematic or unsuitable APIs early in the development. The work will be divided in four main work packages:

  • Risk assessment – Paper exercise aimed at identification of critical API and formulation properties.
  • Exploring the potential of platform formulations – characterization of the process and its limit when using currently available platform formulations;
  • Creating innovative solutions for formulation for continuous direct compression.
  • Definition of Continuous Manufacturing Classification System and method of establishing API classification;
  • Validation of the cMCS concept.

The implementation of the program will take place at Hovione's premises, in close collaboration with UNIDEMI/FCT NOVA.

The scientific supervisors of the program will be prof. António Grilo (Institute Supervisor) and Slavomíra Doktorovová da Silva (Hovione Supervisor).

The scholarship has a maximum duration of 4 years; it is granted on a full-time basis and is awarded annually, for periods of 12 consecutive months and automatically renewable, unless under the applicable legislation the scholar fails to fulfill his / her assigned duties. The scholarship is scheduled to start in October 2021 on an exclusive basis.

This call is addressed to anyone who is eligible to participate in the Program.

The call t is open between 1st and the 30th of June 2021.

Applications must be completed through a motivation letter to, mentioning the Program and this announcement, together with the following documents: Letter of Motivation, detailed Curriculum Vitae of the applicant [proving the above mentioned requirements] copy of relevant diploma, a valid email address and a contact telephone number, contact details of 2 persons as referrals and other documents which the applicant considers relevant for the evaluation of his / her application.

Only applications received until 17:00 on the 30th of June 2021 will be considered.


The selection methods are as follows:

  1. Psychotechnical tests (eliminatory factor) - candidates with negative results will not be considered for points ii, iii, iv and v;
  2. Scientific merit taking into account the curriculum vitae of the candidate, degree / masters grade (minimum 16/20), participation in research projects, suitability of the candidate's profile to the Program theme and candidate experience in the Program theme;
  3. Level of English;
  4. Motivation Letter
  5. Interview

Each item will be scored on a scale of 0-20, with the following weights: Curriculum vitae and experience (40%), English (10%), motivation letter (10%) and interview (40%).

The evaluation of the applications will be carried out by the Evaluation Panel defined in accordance with Article 17 of the FCT Research Grants Regulation.

The evaluation panel comprises the Hovione's Scientific Advisors panel, Hovione Innovation Manager and Hovione Business Partner R&D.

The results of the evaluation, presented in descending order, are published through the Hovione website and sent to the applicants within the deadline set in Article 18 of the FCT Research Grants Regulation.

The scholarship has a value of € 1.104.64, which is in accordance with the table of values for scholarships awarded directly by FCT, I.P., and is 100% funded by Hovione. The scholarship payment will be made monthly.
The tuition fees of the Academic Institution will also be paid entirely by Hovione.

Only requests made by e-mail to will be considered.